Injections for Arthritic Knees – Viscosupplementation

• Osteoarthritic synovial fluid has reduced elasticity and viscosity, reduced molecular weight and reduced hyaluronan concentration.
• Viscosupplementation with Hyaluronan replaces and replenishes diseased synovial fluid with a temporary synovial fluid prosthesis that has long-term clinical benefits.

SYNVISC(r) (hylan G-F 20)

• Elastoviscosity similar to that of the synovial fluid of healthy 18- to 27-year-olds
• Designed as a synovial fluid prosthetic device
• A series of 3 injections can provide OA knee pain relief for up to 6 month
• Generally demonstrated to be safe in clinical trials and clinical practice

Synvisc(r) Has a Higher Molecular Weight

Left: Supartz(r) (sodium hyaluronate)
MW 0.6-1
Center: Synvisc(r) (Hylan G-F 20)
hylan A MW 6 million
Right: Hyalgan(r) (sodium hyaluronate)
MW 0.5-0.7