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(65) 6836 6636

(65) 8896 3604

Call Us
(65) 6836 6636

Autologous Protein Solution APS (nSTRIDE) Injection

Osteoarthritis is associated with an imbalance of inflammatory ‘bad proteins’ and anti-inflammatory ‘good proteins’

nSTRIDE Autologous Protein Solution (APS) is a new autologous (from your own body) therapy designed to:

  • Treat pain
  • Slow the progression of cartilage degradation and destruction in the knee
  • Achieved by injecting high concentrations of anti-inflammatory proteins

nSTRIDE APS Benefits include:

  • Decreased pain
  • Decreased cartilage degeneration
  • Improves mobility
  • Stimulates cell proliferation
  • Delays the need for invasive surgery for up to 2 years
  • Totally natural
  • Single injection


Duration effects of a single intra-articular injection of Autologous Protein Solution (APS) in patients with knee osteoarthritis (OA).

Kon E, Engebretsen L, Verdonk P, Nehrer S, Filardo G. Clinical outcomes of an Autologous Protein Solution Injection for Knee Osteoarthritis: A 1-year Pilot Double-Blinded Randomized Controlled Trial. American Journal of Sports Medicine 2018;46(1):171-80.


Autologous anti-inflammatories (AAI) are a class of blood-derived products with high concentrations of anti-inflammatory cytokines that are currently being investigated for the treatment of mild to moderate knee osteoarthritis (OA) to determine if they can ameliorate symptoms longer or better than traditional intra-articular injections such as hyaluronic acid (HA) and steroids. The purpose of this evaluation is to determine the duration of effect from a single injection of APS before patients elect a new treatment course.

Methods and Materials

Forty-six patients underwent a 2:1 randomization process to either one single injection of APS (n=31) or saline (n=15) (NCT02138890). APS was prepared with the nSTRIDE APS Kit (Zimmer Biomet).  The 12 month double-blind outcomes of the double-blind portion of the trial were previously published(1). The APS cohort was asked to participate in unblinded long-term follow-up. Efficacy endpoints of pain and function over time (WOMAC LK 3.1, KOOS, and VAS) were measured as a change from baseline to each time point. Quality of life (SF-36), OMERACT-OARSI responder criteria, rescue medication usage, as well as yearly x-rays and 24 month MRI imaging were completed.


Survivorship of the APS cohort that agreed to long-term follow-up was 71% at 3 years. At 36 months, the mean WOMAC Pain improvement was 70%(Figure 2)(7.8 ± 4.0) in the APS cohort, which was a significant improvement compared to the baseline score(p<0.0001). APS cohort patients also showed a statistically significant improvement in their KOOS pain score (114%,33.3 ± 22.0; p<0.0001) and VAS pain score (42.7%, 2.0 ± 3.3; p=0.0012).


Intra-articular injections of APS for mild to moderate knee OA was safe and a portion of patients continue to have pain relief 3 years after a single injection. Clinical investigation (NCT03182374) to determine the long-term efficacy compared to a single injection hyaluronic acid is currently ongoing.


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Dr HC Chang

  • 16 years of experience in surgical and non-surgical procedures in sports injuries as a Sports Orthopaedic Specialist in Singapore.
  • Received multiple awards and accolades in the Orthopaedic field.
  • He is a USA Sports Medicine Fellowship trained Orthopaedic Surgeon and is a member of the Arthroscopy Association of North America as well as the International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine.
  • Published many acclaimed articles on Sports Medicine. If you are experiencing one or more of the symptoms mentioned above, it is important to get a prompt and accurate diagnosis to determine the severity of your injury and get proper treatment immediately.


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